Wednesday, July 3, 2013

Vodafone launches a 4G mobile hotspot, suffers from premature dispensation

Vodafone launches a 4G mobile hotspot, suffers from premature dispensation

Camping outside a store for weeks on end has been done to death now, so what can you do to score some early adopter cred? How about buying a device to use on a service that doesn't exist... yet? That's Vodafone's thinking behind launching its first 4G wireless hotspot, two months before its LTE service begins rolling out. The Vodafone R212 will connect up to 10 devices simultaneously, comes with a 32GB SD card reader, a 2,800mAh battery and will, thankfully, connect to the company's 3G network as well. It'll set you back £39 up-front if you sign up for a plan offering you 1GB of monthly data for £10 a month.

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Via: Pocket-lint

Source: Vodafone

Source: http://feeds.engadget.com/~r/weblogsinc/engadget/~3/uypMEM83yFE/

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Tuesday, July 2, 2013

Cloud behavior expands habitable zone of alien planets

July 1, 2013 ? A new study that calculates the influence of cloud behavior on climate doubles the number of potentially habitable planets orbiting red dwarfs, the most common type of stars in the universe. This finding means that in the Milky Way galaxy alone, 60 billion planets may be orbiting red dwarf stars in the habitable zone.

Researchers at the University of Chicago and Northwestern University based their study, which appears in Astrophysical Journal Letters, on rigorous computer simulations of cloud behavior on alien planets. This cloud behavior dramatically expanded the habitable zone of red dwarfs, which are much smaller and fainter than stars like the sun.

Current data from NASA's Kepler Mission, a space observatory searching for Earth-like planets orbiting other stars, suggest there is approximately one Earth-size planet in the habitable zone of each red dwarf. The UChicago-Northwestern study now doubles that number.

"Most of the planets in the Milky Way orbit red dwarfs," said Nicolas Cowan, a postdoctoral fellow at Northwestern's Center for Interdisciplinary Exploration and Research in Astrophysics. "A thermostat that makes such planets more clement means we don't have to look as far to find a habitable planet."

Cowan is one of three co-authors of the study, as are UChicago's Dorian Abbot and Jun Yang. The trio also provide astronomers with a means of verifying their conclusions with the James Webb Space Telescope, scheduled for launch in 2018.

The formula for calculating the habitable zone of alien planets -- where they can orbit their star while still maintaining liquid water at their surface -- has remained much the same for decades. But the formula largely neglects clouds, which exert a major climatic influence.

"Clouds cause warming, and they cause cooling on Earth," said Abbot, an assistant professor in geophysical sciences at UChicago. "They reflect sunlight to cool things off, and they absorb infrared radiation from the surface to make a greenhouse effect. That's part of what keeps the planet warm enough to sustain life."

A planet orbiting a star like the sun would have to complete an orbit approximately once a year to be far enough away to maintain water on its surface. "If you're orbiting around a low mass or dwarf star, you have to orbit about once a month, once every two months to receive the same amount of sunlight that we receive from the sun," Cowan said.

Tightly orbiting planets

Planets in such a tight orbit would eventually become tidally locked with their sun. They would always keep the same side facing the sun, like the moon does toward Earth. Calculations of the UChicago-Northwestern team indicate that the star-facing side of the planet would experience vigorous convection and highly reflective clouds at a point that astronomers call the sub-stellar region. At that location the sun always sits directly overhead, at high noon.

The team's three-dimensional global calculations determined for the first time the effect of water clouds on the inner edge of the habitable zone. The simulations are similar to the global climate simulations that scientists use to predict Earth climate. These required several months of processing, running mostly on a cluster of 216 networked computers at UChicago. Previous attempts to simulate the inner edge of exoplanet habitable zones were one-dimensional. They mostly neglected clouds, focusing instead on charting how temperature decreases with altitude.

"There's no way you can do clouds properly in one-dimension," Cowan said. "But in a three-dimensional model, you're actually simulating the way air moves and the way moisture moves through the entire atmosphere of the planet."

These new simulations show that if there is any surface water on the planet, water clouds result. The simulations further show that cloud behavior has a significant cooling effect on the inner portion of the habitable zone, enabling planets to sustain water on their surfaces much closer to their sun.

Astronomers observing with the James Webb Telescope will be able to test the validity of these findings by measuring the temperature of the planet at different points in its orbit. If a tidally locked exoplanet lacks significant cloud cover, astronomers will measure the highest temperatures when the dayside of the exoplanet is facing the telescope, which occurs when the planet is on the far side of its star. Once the planet comes back around to show its dark side to the telescope, temperatures would reach their lowest point.

But if highly reflective clouds dominate the dayside of the exoplanet, they will block a lot of infrared radiation from the surface, said Yang, a postdoctoral scientist in geophysical sciences at UChicago. In that situation "you would measure the coldest temperatures when the planet is on the opposite side, and you would measure the warmest temperatures when you are looking at the night side, because there you are actually looking at the surface rather than these high clouds," Yang said.

Earth-observing satellites have documented this effect. "If you look at Brazil or Indonesia with an infrared telescope from space, it can look cold, and that's because you're seeing the cloud deck," Cowan said. "The cloud deck is at high altitude, and it's extremely cold up there."

If the James Webb Telescope detects this signal from an exoplanet, Abbot noted, "it's almost definitely from clouds, and it's a confirmation that you do have surface liquid water."

Source: http://feeds.sciencedaily.com/~r/sciencedaily/space_time/nasa/~3/g9tQ0dZnz1k/130701135131.htm

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The ribosome: New target for antiprion medicines

July 2, 2013 ? New research results from Uppsala University, Sweden, show that the key to treating neurodegenerative prion diseases such as mad cow disease and Creutzfeldt-Jakob disease may lie in the ribosome, the protein synthesis machinery of the cell. The results were recently published in the Journal of Biological Chemistry.

Prion diseases are fatal neurodegenerative diseases caused by misfolding of prion proteins. Examples of prion diseases are scrapie in sheep, mad cow disease and Creutzfeldt-Jakob disease in human.

What triggers misfolding of the prion proteins to the amyloid disease form is an open question. The inadequate knowledge in the field about the factors involved in prion formation makes the discovery of effective medicines for prion diseases rather challenging.

"We have now shown that the protein folding activity of the ribosome (PFAR) is most likely involved in prion propagation and thus, can be a specific target for antiprion medicines. If we understand the mechanism fully, we will be able to find ways to stop that too.," says Suparna Sanyal, senior lecturer at the Department of Cell and Molecular Biology, Uppsala University .

The ribosome is the protein synthesis machinery of the cell. The mechanism of protein synthesis by the ribosome is well characterized, while PFAR is a rather recent discovery. PFAR is a ribosomal RNA dependent function of the large subunit of the ribosome irrespective of its source. The PFAR center closely overlaps the peptidyl transferase center although the nucleobases responsible for these two functions are not all common.

"Our results show that two prion inhibitors 6-aminophenanthridine and guanabenz acetate implement antiprion activity by binding to ribosomal RNA and inhibiting PFAR. Thus, the ribosome and more specifically PFAR is the new target for antiprion medicines. Furthermore, we have developed an in vitro PFAR assay, which can be used as a platform for screening prion inhibitors in a high-throughput fashion. This assay is much more time and cost-effective than standard prion assays," says Suparna Sanyal.

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The above story is reprinted from materials provided by Uppsala Universitet, via AlphaGalileo.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.


Journal Reference:

  1. Y. Pang, S. Kurella, C. Voisset, D. Samanta, D. Banerjee, A. Schabe, C. Das Gupta, H. Galons, M. Blondel, S. Sanyal. The Antiprion Compound 6-Aminophenanthridine Inhibits the Protein Folding Activity of the Ribosome by Direct Competition. Journal of Biological Chemistry, 2013; 288 (26): 19081 DOI: 10.1074/jbc.M113.466748

Note: If no author is given, the source is cited instead.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/top_news/top_environment/~3/Rj_jDfOp4cM/130702100120.htm

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Researchers find 2 new methods to determine ALK status

Researchers find 2 new methods to determine ALK status [ Back to EurekAlert! ] Public release date: 1-Jul-2013
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Contact: Kristal Griffith
Kristal.Griffith@iaslc.org
720-325-2952
International Association for the Study of Lung Cancer

Tests continue trend in personalized medicine for lung cancer patients

DENVER The implementation of personalized health care in cancer relies on the identification and characterization of cancer biomarkers and the availability of accurate detection systems and therapies for those biomarkers. Anaplastic lymphoma kinase (ALK), a tyrosine kinase, is a more recently characterized cancer biomarker in nonsmall-cell lung cancer (NSCLC). To identify NSCLC patients with ALK gene rearrangement in clinical trials, researchers have used the methods known as fluorescence in situ hybridization (FISH) or immunohistochemistry (IHC). While IHC is a less complex and less costly technology than FISH, both methods present challenges.

Now research published in the August issue of the Journal of Thoracic Oncology (JTO), describes the development and evaluation of two new methodologies.

To improve IHC assay sensitivity, the researchers incorporated the novel, nonendogenous hapten 3-hydroxy-2-quinoxaline and tyramide amplification into a diaminobenzidine and horseradish peroxidasebased assay. The new detection system proved to be very useful for detecting low levels of ALK protein expression in NSCLC.

They also developed a brightfield IHCin situ hybridization combination assay (geneprotein assay) for the concurrent visualization of ALK protein and ALK gene arrangement. This allows the concurrent visualization of ALK gene and ALK protein status in single cells, allowing more accurate ALK status determination even in heterogeneous specimens.

The authors say, "this tool for simultaneously assessing both ALK protein expression (IHC) and ALK gene rearrangement (ISH) in NSCLC will be valuable for research on the mechanisms driving ALK-dependent malignancies and as a model of new diagnostic approach for identifying patients who might benefit from ALK-targeted therapies. More generally, it also provides proof of concept for the development of new methodologies for the simultaneous assessment of gene structure and protein-expression status in a single cell.

###

The lead author of the study is Dr. Hiroaki Nitta. Dr. Koji Tsuta is an IASLC co-author.

About the IASLC:

The International Association for the Study of Lung Cancer (IASLC) is the only global organization dedicated to the study of lung cancer. Founded in 1974, the association's membership includes more than 3,500 lung cancer specialists in 80 countries. To learn more about IASLC please visit http://www.iaslc.org.


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AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.


Researchers find 2 new methods to determine ALK status [ Back to EurekAlert! ] Public release date: 1-Jul-2013
[ | E-mail | Share Share ]

Contact: Kristal Griffith
Kristal.Griffith@iaslc.org
720-325-2952
International Association for the Study of Lung Cancer

Tests continue trend in personalized medicine for lung cancer patients

DENVER The implementation of personalized health care in cancer relies on the identification and characterization of cancer biomarkers and the availability of accurate detection systems and therapies for those biomarkers. Anaplastic lymphoma kinase (ALK), a tyrosine kinase, is a more recently characterized cancer biomarker in nonsmall-cell lung cancer (NSCLC). To identify NSCLC patients with ALK gene rearrangement in clinical trials, researchers have used the methods known as fluorescence in situ hybridization (FISH) or immunohistochemistry (IHC). While IHC is a less complex and less costly technology than FISH, both methods present challenges.

Now research published in the August issue of the Journal of Thoracic Oncology (JTO), describes the development and evaluation of two new methodologies.

To improve IHC assay sensitivity, the researchers incorporated the novel, nonendogenous hapten 3-hydroxy-2-quinoxaline and tyramide amplification into a diaminobenzidine and horseradish peroxidasebased assay. The new detection system proved to be very useful for detecting low levels of ALK protein expression in NSCLC.

They also developed a brightfield IHCin situ hybridization combination assay (geneprotein assay) for the concurrent visualization of ALK protein and ALK gene arrangement. This allows the concurrent visualization of ALK gene and ALK protein status in single cells, allowing more accurate ALK status determination even in heterogeneous specimens.

The authors say, "this tool for simultaneously assessing both ALK protein expression (IHC) and ALK gene rearrangement (ISH) in NSCLC will be valuable for research on the mechanisms driving ALK-dependent malignancies and as a model of new diagnostic approach for identifying patients who might benefit from ALK-targeted therapies. More generally, it also provides proof of concept for the development of new methodologies for the simultaneous assessment of gene structure and protein-expression status in a single cell.

###

The lead author of the study is Dr. Hiroaki Nitta. Dr. Koji Tsuta is an IASLC co-author.

About the IASLC:

The International Association for the Study of Lung Cancer (IASLC) is the only global organization dedicated to the study of lung cancer. Founded in 1974, the association's membership includes more than 3,500 lung cancer specialists in 80 countries. To learn more about IASLC please visit http://www.iaslc.org.


[ Back to EurekAlert! ] [ | E-mail | Share Share ]

?


AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.


Source: http://www.eurekalert.org/pub_releases/2013-07/iaft-rft070113.php

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Monday, July 1, 2013

Join the Engadget HD Podcast live on Ustream at 8:30PM ET

Join the Engadget HD Podcast live on Ustream at 530PM ET

It's Monday, and you know what that means; another Engadget HD Podcast. We hope you will join us live when the Engadget HD podcast starts recording at 8:30PM. If you'll be joining us, be sure to go ahead and get ready by reviewing the list of topics after the break, then you'll be ready to participate in the live chat.

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Source: http://feeds.engadget.com/~r/weblogsinc/engadget/~3/H6S676n2ke0/

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Removing nerves connecting kidney to the brain shown to reduce high blood pressure

July 1, 2013 ? A new technique that involves removing the nerves connecting the kidney to the brain has shown to significantly reduce blood pressure and help lower the risk of stroke, heart and renal disease in patients. The procedure, which has very few side effects, has already shown promising results in hard-to-treat cases of high blood pressure.

The technique, published in the journal Hypertension, was performed by a team led by Professor Julian Paton at the University of Bristol who found that in an animal model of hypertension removing nerves connecting the kidney to the brain reduced blood pressure and improved its long-term stability.

Inspired by these results, cardiologists Dr Angus Nightingale and Dr Andreas Baumbach from the Bristol Heart Institute (BHI) adopted the technique called "renal denervation" to remove the nerves to the kidney in patients with high blood pressure.

The procedure, which has been successfully trialled on 19 patients at the BHI, is performed using a fine tube that is inserted in an artery in the patient's leg and positioned in the artery feeding blood to the patient's kidneys. The nerves to the kidney are around the artery and ablated by radio-frequency energy that is emitted from the tube.

The breakthrough is due to a new collaboration involving scientists at the University of Bristol and cardiologists at the BHI, who have joined forces to form the CardioNomics high blood pressure team. Together, they hope to tackle this major health problem by taking findings from the laboratory and translating them into clinical practice. The CardioNomics team have just been awarded ?100,000 grant from Medtronic to further improve the technique and expand patient trials.

Dr Nightingale, who runs the Specialist Hypertension Clinic at the BHI, said: "We have used renal denervation in patients who have hard-to-treat blood pressure. Similar to the results from the basic science experiments, we have also seen reductions in blood pressure which has been essential for reducing the risk of heart and renal disease, and stroke in our patients. This is an exciting new treatment for these patients who have struggled with high blood pressure which tablets are not controlling."

Dr Baumbach, an interventional cardiologist who performed the treatment, added: "The technique is very straight forward, performed as a day case and there are no side-effects. It is becoming a popular technique for patients with both resistance and poor tolerability to high blood pressure medication."

Professor Julian Paton, who led the research at the University's School of Physiology and Pharmacology, said: "The problem with high blood pressure is that patients develop resistance to their tablets or unpleasant side effects. Our new interventional approaches are based on studies where we have found causative mechanisms generating high blood pressure so we think that they will be most efficacious in patients. And, with luck, they will also mean less pill taking too."

Source: http://feeds.sciencedaily.com/~r/sciencedaily/most_popular/~3/6Xw4ebqM_ww/130701163849.htm

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El Nino unusually active in the late 20th century: Is it because of global warming?

June 30, 2013 ? Spawning droughts, floods, and other weather disturbances world-wide, the El Ni?o -- Southern Oscillation (ENSO) impacts the daily life of millions of people. During El Ni?o, Atlantic hurricane activity wanes and rainfall in Hawaii decreases while Pacific winter storms shift southward, elevating the risk of floods in California.

The ability to forecast how ENSO will respond to global warming thus matters greatly to society. Providing accurate predictions, though, is challenging because ENSO varies naturally over decades and centuries. Instrumental records are too short to determine whether any changes seen recently are simply natural or attributable to human-made greenhouse gases. Reconstructions of ENSO behavior are usually missing adequate records for the tropics where ENSO develops.

Help is now underway in the form of a tree-ring record reflecting ENSO activity over the past seven centuries. Tree-rings have been shown to be very good proxies for temperature and rainfall measurements. An international team of scientists spearheaded by Jinbao Li and Shang-Ping Xie, while working at the International Pacific Research Center, University of Hawaii at Manoa, has compiled 2,222 tree-ring chronologies of the past seven centuries from both the tropics and mid-latitudes in both hemispheres. Their work is published in the June 30, 2013 online issue of Nature Climate Change.

The inclusion of tropical tree-ring records enabled the team to generate an archive of ENSO activity of unprecedented accuracy, as attested by the close correspondence with records from equatorial Pacific corals and with an independent Northern Hemisphere temperature reconstruction that captures well-known teleconnection climate patterns.

These proxy records all indicate that ENSO was unusually active in the late 20th century compared to the past seven centuries, implying that this climate phenomenon is responding to ongoing global warming.

"In the year after a large tropical volcanic eruption, our record shows that the east-central tropical Pacific is unusually cool, followed by unusual warming one year later. Like greenhouse gases, volcanic aerosols perturb the Earth's radiation balance. This supports the idea that the unusually high ENSO activity in the late 20th century is a footprint of global warming," explains lead author Jinbao Li.

"Many climate models do not reflect the strong ENSO response to global warming that we found," says co-author Shang-Ping Xie, meteorology professor at the International Pacific Research Center, University of Hawaii at Manoa and Roger Revelle Professor at Scripps Institution of Oceanography, University of California at San Diego. "This suggests that many models underestimate the sensitivity to radiative perturbations in greenhouse gases. Our results now provide a guide to improve the accuracy of climate models and their projections of future ENSO activity. If this trend of increasing ENSO activity continues, we expect to see more weather extremes such as floods and droughts."

Source: http://feeds.sciencedaily.com/~r/sciencedaily/top_news/~3/li4efH1FPxs/130630145025.htm

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